Journal of Microbiology and Biotechnology
The Korean Society for Microbiology and Biotechnology publishes the Journal of Microbiology and Biotechnology.

2015 ; Vol.25-10: 1583~1588

AuthorMaha Al-Asmakh, Fahad Zadjali
Place of dutyDepartment of Health Sciences, College of Arts and Sciences, Qatar University, P.O. Box 2713, Doha, Qatar,Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, 171 77 Stockholm, Sweden
TitleUse of Germ-Free Animal Models in Microbiota-Related Research
PublicationInfo J. Microbiol. Biotechnol.2015 ; Vol.25-10
AbstractThe large intestine is a home for trillions of microbiota, which confer many benefits on the host, including production of vitamins, absorption of nutrients, pathogen displacement, and development of the immune system. For several decades, germ-free animals have been used to study the interaction between the host and its microbiota. This minireview describes the technical aspects for establishing and maintaining germ-free animals and highlights the advantages and disadvantages for germ-free animals as experimental models.
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Key_wordGerm-free animals, Germ-free mice, microbiota, Isolator technology



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