2015 ; Vol.25-5: 637~647
|Author||Yoon-E Choi, Jin-Kyu Rhee, Hyun-Soo Kim, Joon-Woo Ahn, Hyemin Hwang, Ji-Won Yang|
|Place of duty||Division of Environmental Science and Ecological Engineering, College of Life Sciences and Biotechnology, Korea University, Seoul, 136-713, Republic of Korea|
|Title||Chemical Genetics Approach Reveals Importance of cAMP and MAP Kinase Signaling to Lipid and Carotenoid Biosynthesis in Microalgae|
J. Microbiol. Biotechnol.2015 ;
|Abstract||In this study, we attempted to understand signaling pathways behind lipid biosynthesis by
employing a chemical genetics approach based on small molecule inhibitors. Specific signaling
inhibitors of MAP kinase or modulators of cAMP signaling were selected to evaluate the
functional roles of each of the key signaling pathways in three different microalgal species:
Chlamydomonas reinhardtii, Chlorella vulgaris, and Haematococcus pluvialis. Our results clearly
indicate that cAMP signaling pathways are indeed positively associated with microalgal lipid
biosynthesis. In contrast, MAP kinase pathways in three microalgal species are all negatively
implicated in both lipid and carotenoid biosynthesis.|
|Key_word||Microalgal signaling pathways, Lipid biosynthesis, Carotenoid biosynthesis, MAP kinase, cAMP signaling|
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