2015 ; Vol.25-5: 629~636
|Author||Usha Kiranmayi Mangamuri, Muvva Vijayalakshmi, Sudhakar Poda, Bramanandam Manavathi, Ch. Bhujangarao, Y. Venkateswarlu|
|Place of duty||Department of Botany and Microbiology, Acharya Nagarjuna University, Guntur-522510, Andhra Pradesh, India|
|Title||Bioactive Metabolites Produced by Pseudonocardia endophytica VUK-10 from Mangrove Sediments: Isolation, Chemical Structure Determination and Bioactivity|
J. Microbiol. Biotechnol.2015 ;
|Abstract||Chemical investigation of the actinobacterial isolate Pseudonocardia endophytica VUK-10 has led
to the segregation of two known bioactive compounds, namely 4-(2-acetamidoethyl) phenyl
acetate and 4-((1, 4-dioxooctahydropyrrolo [1, 2-a] pyrazin-3-yl) methyl) phenyl acetate. The
strain was isolated from a sediment sample of the Nizampatnam mangrove ecosystem, south
coastal Andhra Pradesh, India. The chemical structure of the active compounds was
established on the basis of spectroscopic analysis, including 1H NMR and 13C NMR
spectroscopies, FTIR, and EIMS. The antimicrobial and cytotoxic activities of the bioactive
compounds produced by the strain were tested against opportunistic and pathogenic bacteria
and fungi and on MDA-MB-231, OAW, HeLa, and MCF-7 cell lines. The compounds exhibited
antimicrobial activities against gram-positive and gram-negative bacteria and fungi and also
showed potent cytotoxic activity against MDA-MB-231, OAW, HeLa, and MCF-7 cell lines.
This is the first example for this class of bioactive compounds isolated from Pseudonocardia of
|Key_word||Mangrove Ecosystem, Pseudonocardia endophytica, Bioactive Compounds, 4-(2-acetamidoethyl) phenyl acetate, 4-((1, 4-dioxooctahydropyrrolo [1, 2-a] pyrazin-3-|
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