2013 ; Vol.23-12: 1802~1805
|Author||Hansoo Kim, Jeong-Hoon Kim, Phil Young Lee, Kwang-Hee Bae, Sayeon Cho, Byoung Chul Park, Heungsop Shin, Sung Goo Park|
|Place of duty||Medical Proteomics Research Center, KRIBB, Daejeon 305-806, Republic of Korea|
|Title||Ginsenoside Rb1 is transformed into Rd and Rh2 by Microbacterium trichothecenolyticum|
J. Microbiol. Biotechnol.2013 ;
|Abstract||Ginsenosides are the most important ingredient of ginseng and are known to possess many
pharmacological and biological effects. Rb1, a major protopanaxadiol ginsenoside, is the most
abundant ginsenoside in Panax ginseng C.A Meyer and can be hydrolyzed into more
pharmaceutically potent minor ginsenosides. To identify a microorganism that is capable of
converting Rb1 into other ginsenosides, we screened 12 Microbacterium spp., and M.
trichothecenolyticum was identified as a likely candidate. M. trichothecenolyticum converted Rb1
into Rd and then into Rh2 based on TLC and HPLC analyses of reaction products. This
biotransformation method can be easily applied for mass production of Rd and Rh2 by using
|Key_word||biotransformation, ginsenoside, Microbacterium, TLC|
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