Journal of Microbiology and Biotechnology
The Korean Society for Microbiology and Biotechnology publishes the Journal of Microbiology and Biotechnology.

2013 ; Vol.23-12: 1802~1805

AuthorHansoo Kim, Jeong-Hoon Kim, Phil Young Lee, Kwang-Hee Bae, Sayeon Cho, Byoung Chul Park, Heungsop Shin, Sung Goo Park
Place of dutyMedical Proteomics Research Center, KRIBB, Daejeon 305-806, Republic of Korea
TitleGinsenoside Rb1 is transformed into Rd and Rh2 by Microbacterium trichothecenolyticum
PublicationInfo J. Microbiol. Biotechnol.2013 ; Vol.23-12
AbstractGinsenosides are the most important ingredient of ginseng and are known to possess many pharmacological and biological effects. Rb1, a major protopanaxadiol ginsenoside, is the most abundant ginsenoside in Panax ginseng C.A Meyer and can be hydrolyzed into more pharmaceutically potent minor ginsenosides. To identify a microorganism that is capable of converting Rb1 into other ginsenosides, we screened 12 Microbacterium spp., and M. trichothecenolyticum was identified as a likely candidate. M. trichothecenolyticum converted Rb1 into Rd and then into Rh2 based on TLC and HPLC analyses of reaction products. This biotransformation method can be easily applied for mass production of Rd and Rh2 by using Rb1.
Key_wordbiotransformation, ginsenoside, Microbacterium, TLC
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