2014 ; Vol.24-1: 127~131
|Author||Hoyong Lee, Young-Tae Ahn, Se-Hoon Park, Do-Young Park, Young-Woo Jin, Cha Soon Kim, Sang Hyun Sung, Chul-Sung Huh, Dong-Hyun Kim|
|Place of duty||Korea Yakult Co., Ltd., Yongin 449-901, Republic of Korea|
|Title||Lactobacillus plantarum HY7712 Protects Against the Impairment of NK-Cell Activity Caused by Whole-Body γ-Irradiation in Mice|
J. Microbiol. Biotechnol.2014 ;
|Abstract||While searching for lactic acid bacteria that can restore aging-impaired immune responses, we
isolated the Toll-like receptor (TLR) 2/NF-κB-activating strain Lactobacillus plantarum HY7712
from kimchi and investigated its immunomodulating effect in whole-body γ-irradiated mice.
Exposure to HY7712 strongly activated NF-κB signaling in RAW264.7 cells, but inhibited
lipopolysaccharide-stimulated NF-κB activation. Moreover, HY7712 protected against the
downregulation of interferon (IFN)-γ and upregulation of interleukin (IL)-13 caused by
γ-irradiation in mice. In mice, γ-irradiation impaired NK-cell activity against YAC-1 tumor
cells, but following HY7712 exposure, the activity of NK cells was restored to 91.5% of the
level measured in control mice (p < 0.05). These findings suggest that HY7712 activates the
TLR2/NF-κB signaling pathway and protects against the impairment of NK-cell activity
caused by γ-irradiation or aging.|
|Key_word||Lactobacillus plantarum HY7712, γ-irradiation, aging, NK cell activity|
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